Mapping a complex evolutionary history
S Gravel "Mapping a complex evolutionary history", Science 387, 6741 p.1352 (2025)
Mapping human migrations using the ARG
Publications
You can find most of the lab articles on Simon Gravel's Google Scholar profile.
Some selected publications:
Humans origins in Africa
AP Ragsdale et al, "A weakly structured stem for human origins in Africa", Nature 617, 755 (2023)
Exploring the origins of modern humans. Media coverage: NYT Nat Geo, Nature Ecology and Evolution, Le Figaro Smithsonian Magazine, reuters
Genetics using large genealogies in Quebec
L Anderson-Trocmé et al, "Genes, Genealogies, and geographies of Quebec", Science 380, 849 (2023)
Exploring the emergence of population structure in Quebec. Version française ici!. Media coverage: La Presse, Les années Lumière, Radio-Canada, tout un matin, Québec Science, Le figaro, Science et avenir
Variational Inference with Polygenic Risk Scores
S. Zabad, S. Gravel, Y. Li "Fast and Accurate Bayesian Polygenic Risk Modeling with Variational Inference." AJHG. 110, 1 (2023)
A variational approach to polygenic risk prediction, implemented as the VIPRS software.
Dara visualization and topological modelling
A. Diaz-Papkovich, L. Anderson-Trocmé, C. Ben-Eghan, S. Gravel (2019). "UMAP reveals cryptic population structure and phenotype heterogeneity in large genomic cohorts." PLoS Genet. 15(11): e1008432. https://doi.org/10.1371/journal.pgen.1008432.
A method of dimensionality reduction and visualization of population genetic data.
Inference using two locus statistics
A.P. Ragsdale, S. Gravel, (2019). "Models of archaic admixture and recent history from two-locus statistics." PLoS Genet. 1008204.
A likelihood approach to infer complex demographic models using two-locus statistics
Inference using efficient computation of the allele frequency spectrum
J. Jouganous, W. Long, A.P. Ragsdale, S. Gravel, (2017). "Inferring the Joint Demographic History of Multiple Populations: Beyond the Diffusion Approximation ." Genetics 206 (3).
Recursion equations help infer demographic models from allele frequency data